San Sisto Vacations from $1,515

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Your San Sisto Vacation

An easy way to experience this interesting city is with a customized San Sisto vacation package. Stay in the neighborhood of San Biagio della Valle, which is good for views, nature and history or go someplace else — our package deals are all about you. Make your trip to San Sisto even more fun by including some sightseeing. Piazza IV Novembre, Rocca Paolina and Basilica San Pietro are some of the major attractions worth exploring. Expedia is here to help you escape your daily routine. Tailor your vacation to San Sisto to suit your style of travel, whatever that may be.

The Latest San Sisto vacation packages

Price found within the past 48 hours. Click for updated prices.
Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze

4 out of 5
Price was $1,739, price is now $1,515 per person
$1,515
per person
Dec 8 - Dec 13
found 11 hours ago
Roundtrip flight included
San Juan (SJU) to Ancona (AOI)
9.2/10 Wonderful! (248 reviews)
Great grounds, lovely bedroom with character. Very peaceful also

Reviewed on Aug 19, 2025

Borgobrufa Spa Resort Adults Only

Borgobrufa Spa Resort Adults Only

5 out of 5
Price was $2,608, price is now $2,241 per person
$2,241
per person
Dec 8 - Dec 13
found 11 hours ago
Roundtrip flight included
San Juan (SJU) to Ancona (AOI)
9.2/10 Wonderful! (68 reviews)
Nothing much going on other than the spa. It’s relaxing but not necessarily the best.

Reviewed on Nov 10, 2024

V Hotel

V Hotel

4 out of 5
Price was $1,775, price is now $1,581 per person
$1,581
per person
Dec 8 - Dec 13
found 11 hours ago
Roundtrip flight included
San Juan (SJU) to Ancona (AOI)
9.2/10 Wonderful! (9 reviews)
Hotel Priori Secret Garden

Hotel Priori Secret Garden

4 out of 5
Old Town Perugia
Price was $1,778, price is now $1,602 per person
$1,602
per person
Dec 8 - Dec 13
found 11 hours ago
Roundtrip flight included
San Juan (SJU) to Ancona (AOI)
9.6/10 Exceptional! (162 reviews)
Small but comfy room. Excellent location. Bi e breakfast. Friendly staff.

Reviewed on Sep 9, 2025

Hotel Perugia Plaza

Hotel Perugia Plaza

4 out of 5
Price was $1,757, price is now $1,587 per person
$1,587
per person
Dec 8 - Dec 13
found 11 hours ago
Roundtrip flight included
San Juan (SJU) to Ancona (AOI)
8.2/10 Very Good! (202 reviews)
Very clean but few amenities limited dining no bar

Reviewed on Aug 20, 2025

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Discover the most popular places to visit in San Sisto

Piazza IV Novembre which includes a city and heritage architecture as well as a small group of people

Piazza IV Novembre

Located in the heart of Perugia, this small square is surrounded by some of the town’s most impressive landmarks.

Piazza IV Novembre
Perugia showing a city

Corso Vannucci

Learn about the local history of Perugia with a stop at Corso Vannucci. You can enjoy the bars while in the area.

Corso Vannucci
Rocca Paolina showing heritage architecture

Rocca Paolina

Explore a maze of tunnels and alleys, and visit markets, events and exhibitions in the foundations of a 16th-century fortress.

Rocca Paolina

What to do in San Sisto

Perugia: Old Town Walking Tour, Piazza IV Novembre

Perugia: Old Town Walking Tour, Piazza IV Novembre

$35
per adult
Perugia: Old Town Walking Tour, Piazza IV Novembre
Pic nic Deluxe Assisi and wine tasting 5 wines

Pic nic Deluxe Assisi and wine tasting 5 wines

$52
per adult
Pic nic Deluxe Assisi and wine tasting 5 wines
Truffle Hunting Experience in Assisi

Truffle Hunting Experience in Assisi

$65
per adult
Truffle Hunting Experience in Assisi
See all activities in San Sisto

San Sisto Hotel Deals

TH Assisi - Hotel Cenacolo

TH Assisi - Hotel Cenacolo

4 out of 5
Viale Patrono d'Italia 70, Santa Maria degli Angeli, Assisi, PG
$98 nightly
The price is $114 total per night from Nov 2 to Nov 3
$114 total
Nov 2 - Nov 3
Total with taxes and fees
9/10 Wonderful! (587 reviews)
"Everything was great. The breakfast and diner were wonderful. Loved the court yard. I would highly suggest staying there."

Reviewed on Sep 22, 2025

TH Assisi - Hotel Cenacolo
Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Localita Piazzano, C.P. 6, Cortona, AR
Fully refundableReserve now, pay when you stay
$657 nightly
The price is $732 total per night from Oct 12 to Oct 13
$732 total
Oct 12 - Oct 13
Total with taxes and fees
9.6/10 Exceptional! (223 reviews)
"I stayed at Villa di Piazzano for two nights and overall had a lovely experience. The check-in process was seamless, and the staff were warm, professional, and very attentive, which set a great tone from the start. The property itself is absolutely gorgeous, with beautiful grounds and a peaceful ..."

Reviewed on Sep 23, 2025

Villa di Piazzano - Small Luxury Hotel of the World
BV Grand Hotel Assisi

BV Grand Hotel Assisi

4 out of 5
Via Giovanni Renzi No 2, Assisi, PG
$96 nightly
The price is $113 total per night from Oct 29 to Oct 30
$113 total
Oct 29 - Oct 30
Total with taxes and fees
8.4/10 Very Good! (298 reviews)
Good Memories
"Nice big breakfast. Lots of patios to enjoy the great views. Very good front desk service - thanks Simone!"

Reviewed on Sep 17, 2025

BV Grand Hotel Assisi
See all 3,425 properties in San Sisto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Sisto Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Closest Airport
Sant Egidio Airport (PEG)
Top Sights
Cathedral of Saint Lorenzo, Citta della Domenica and Castello di Ramazzano

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Frequently asked questions

How much does a San Sisto vacation package cost?
You can snap up a vacation package to this destination from $1,515 on Expedia. However, how much your vacation to San Sisto costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to San Sisto?
November, December and January are the best times to look for cheap San Sisto vacation packages. Traveling in less busy periods means you'll typically find lower prices on accommodations and flights.
How many days is enough for San Sisto?
With a well-planned itinerary, you can easily tick off the most popular San Sisto sights in a handful of days. But if you want to venture off the beaten track or go on day tours, think about booking your San Sisto vacation for longer.
How to find the best San Sisto package deals?
Use Expedia's handy filters to help you find some great San Sisto package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your escape for midweek, or browse for San Sisto package deals in the off-season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as early as possible.
Is it cheaper to book a San Sisto vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and you could save hundreds of dollars. You'll usually get a better deal than booking each component separately. And you'll still get the flexibility to create a tailored San Sisto vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to San Sisto?
If you're planning a spur-of-the-moment San Sisto getaway, browse our last-minute deals that can be booked up to one week before you take off. Prefer not to wait until the last minute? You can land incredible deals on your hotels and flights by booking well in advance.
How to plan a trip to San Sisto?

  1. Pick the perfect time to travel: Your schedule, preferred season and the type of weather you like can all influence your decision on when to visit San Sisto.
  2. Set your budget: Consider costs such as flights, food and transportation when working out how much to put aside for your trip to San Sisto. Then, select a hotel that matches your budget, whether that's a low-cost stay or a swankier getaway.
  3. Organize your San Sisto getaway with Expedia's trip planning tool: Search for and book hotels and activities all in one place. You can also collaborate with your group to plan an unforgettable trip to San Sisto together.
  4. Set the duration of your trip: Start by making a list of all the sights and activities you'd like to get to in San Sisto. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your hotel and flights: Awesome destination, check. Length of stay, check. Now all that's left is to find a San Sisto vacation package that brings all your bookings together.
  6. Book activities and experiences ahead of time: Whether it's a ticket to a major attraction or a day trip, you won't have to worry about missing out on San Sisto's highlights. Find all the exciting things to do in San Sisto in San Sisto with our dedicated activity guide.

Does Expedia offer Book Now, Pay Later San Sisto vacation packages?
If you're anything like us, you love discovering new places but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the overall cost of your San Sisto break across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure cheap vacation packages with payment plans as soon as you see them.

Explore a world of travel with Expedia

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.